Jerri Blank (Amy Sedaris), a 46-year-old former high school dropout and self-described "junkie whore", is released from prison and returns to her childhood home. She discovers her mother has died, her father, Guy (Dan Hedaya), has remarried to the hateful Sara Blank (Deborah Rush), and she has an arrogant half-brother Derrick (Joseph Cross). To make matters worse, her father is in a "stress-induced coma". Taking the suggestion of the family doctor (Ian Holm) literally, Jerri decides to pick her life back up where she left it, beginning her high school all over again as a freshman at Flatpoint High.
Jerri joins Chuck Noblet's (Stephen Colbert) science fair team, the Fig Neutrons, along with her new friends, Megawatti Sucarnaputri (Carlo Alban) (a spoof on Megawati Sukarnoputri) and Tammi Littlenut (Maria Thayer). Noblet is not pleased to learn that Principal Onyx Blackman (Greg Hollimon) has hired a ringer for their team, Roger Beekman (Matthew Broderick), to ensure that Flatpoint wins, and so Noblet creates a second team. As she struggles to fit in and make her teammates proud, Jerri discovers that though the faces may have changed, the hassles of high school are just the same.
Strangers with Candy is a 2005 comedy film released by THINKFilm, first screened at the Sundance Film Festival. It serves as a prequel to the TV series of the same name. Among the executive producers was David Letterman.