Shake Rattle & Roll X opens the curtains of the first episode: Emergency. JC De Vera and Roxanne Guinoo head the cast as Jay and Dr. Sarah respectively. Here, they will face the wrath of the aswangs which will be led by the cast of Cinemalaya Best Actress Mylene Dizon and Gawad Urian awardee Wendell Ramos. Also with them are Janus Del Prado, Eri Neeman, Denise Laurel, John Lapus and Mr. Cris Daluz.
The full moon looms high one windy night. Jay (JC De Vera) and Dennis (Janus Del Prado) were traveling along a dark highway. They accidentally ran over a pregnant woman (Mylene Dizon) crossing the street. They saw that she has a miscarriage and they immediately carried her to the hospital.
The mysterious woman was not the only patient that night. There was a gay named Julius (John Lapus) who was complaining about fever, an English-speaking man named Eric (Eri Neeman) who keeps whining about the hospital's defective apparatus and a "tortured" and badly injured man who immediately recognized the woman. He attempted to swipe her with his whip, but, it only lead to his death.
Dr. Sarah (Roxanne Guinoo) took charge for the ultrasound of the woman. During the examination, a very eerie sound wailed through the air. They discovered that the infant died while inside the woman's womb. Meanwhile, Sarah went to the bathroom where it was revealed that she was pregnant.
The woman then was transferred into an isolated room. The hospital's head doctor became skeptical about the true nature of the woman. They speculated that she might not be human, He decided to promote this idea, a thing that enraged Sarah.
Back into the isolated room, the woman had a dream of a man beating her with a magic whip: it was the same man who attempted her life as mentioned earlier. She gave a very shrill cry; a scream that gave evidence she was not human but an aswang (vampire or flesh eating witch in Filipino mythology). Together with her husband (Wendell Ramos), who was also an witch, along with their race, they seek vengeance on humans, ready to invade the hospital. The hospital tenants brace themselves for the incoming attack.
Jay became aware of the events happening outside. He, Sarah and the others immediately evacuate to the upper floors as the witch relentlessly break in, killing patients including Julius and Erick. The others hid in the stock room while Jay rescued a young girl from the witch Wife.
Dennis, who had been separated from the team, discovered that dextrose can kill the witches. He was proven wrong: holy water can. They formulated a plan: Jay and Sarah will ward the beasts off while Father Miguel (Cris Daluz) and Dennis will bless the water tank with holy water.
Sarah and Jay were trapped in a locked corridor, with the beasts in pursuit. They used the defibrillator to electrify the beasts. At that moment, Father Miguel and Dennis reached the tank, and Sarah jokingly revealed to Jay that she was pregnant.
At this point, The aswangs morphs into more powerful creatures and launched their final attack. The two confronted the aswangs, while Father Miguel blesses the water in the tank turning it into holy water. They then use this to destroy the Zombies. At the end of the story the Baby zombie opens her/his eyes and uses the final scare of the episode
After tasting the tense of the first episode, Director Topel Lee brings us the second spine-chilling episode: the Class Picture. For the first time, the cast will be led by the famous loveteam of the generation: Kim Chiu and Gerald Anderson. With them is Ms. Jean Garcia who will play the antagonist, Sis. Maria Belonia